{"id":6530,"date":"2023-02-08T12:43:00","date_gmt":"2023-02-08T12:43:00","guid":{"rendered":"https:\/\/the7.io\/cbd\/?p=6530"},"modified":"2024-11-26T17:24:54","modified_gmt":"2024-11-26T16:24:54","slug":"epilepsija-i-kanabinoidi","status":"publish","type":"post","link":"https:\/\/calishop.net\/en\/2023\/02\/08\/epilepsija-i-kanabinoidi\/","title":{"rendered":"Epilepsija i kanabinoidi"},"content":{"rendered":"
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EPILEPSIJA I KANABINOIDI<\/strong><\/h2>
\u00a0<\/div>
\u00a0 \u00a0 \u00a0Napadaji se javljaju kada dio mozga postane pretjerano uzbu\u0111en ili kada \u017eivci u mozgu po\u010dnu pucati na abnormalan na\u010din. Nagla neravnote\u017ea izme\u0111u okida\u010da ekscitacijskih i inhibitornih signala uzrokuje preuzimanje ekscitacijskih sila. Ovo uzbu\u0111enje se zatim \u0161iri na okolne stanice koje po\u010dinju pucati na isti abnormalan na\u010din. Pove\u0107ana ekscitacija ili smanjena inhibicija \u017eiv\u010danih stanica zbog niza mogu\u0107ih inzulta mo\u017ee dovesti do napadaja. Ravnote\u017ea odnosno homeostaza tada je poreme\u0107ena.<\/div>
\u00a0 \u00a0 \u00a0Ne postoje tretmani za temeljne uzroke napadaja, niti tretmani koji bi pouzdano sprije\u010dili razvoj napadaja nakon ozljeda glave. Postoje samo lijekovi za ograni\u010davanje intenziteta ili u\u010destalosti napadaja, a ti lijekovi nisu uvijek u\u010dinkoviti. Zapravo, tre\u0107ina pacijenata s epilepsijom ne uspijeva se osloboditi napadaja \u010dak ni nakon poku\u0161aja i podno\u0161enja dva ili vi\u0161e prikladno propisanih antiepileptika (AED). Konoplja je siguran na\u010din lije\u010denja bez smrtnih slu\u010dajeva zbog nedostatka kanabinoidnih receptora u mo\u017edanom deblu. Naj\u010de\u0161\u0107e nuspojave prijavljene kod pacijenata koji koriste konoplju kao sredstvo za kontrolu napadaja su umor, smanjen apetit i somnolencija. One nestaju prestankom kori\u0161tenja konoplje.<\/div>
Postoje kanabinoidni receptori u hipokampusu, dijelu mozga koji upravlja emocijama i kodiranjem memorije.\u00a0 \u00a0 \u00a0 Abnormalne promjene stanica u hipokampusu uzrok su epilepsije medijalnog temporalnog re\u017enja, jednog od naj\u010de\u0161\u0107ih oblika tog stanja. U ovoj vrsti epilepsije, stanice hipokampusa stvaraju ekscitatornu povratnu petlju koja uzrokuje napadaje. Studije na \u017eivotinjama i ljudima pokazuju da kanabinoidi izgleda \u0161tite normalne stanice hipokampusa i mogu abnormalne stanice u\u010diniti manje aktivnima. Zbog toga je FDA (Agencija za lijekove i hranu) u SAD-u odobrila lijek Epidiolex koji se sastoji od CBD izolata (izolirani oblik Kanabidiola).<\/div>
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\u00a0 \u00a0 \u00a0Tri brazilska znanstvenika \u2013 Fabricio Pamplona, Lorenzo Rolim da Silva i Ana Carolina Coan \u2013 ispitali su podatke iz 11 razli\u010ditih studija koje su uklju\u010divale 670 pacijenata lije\u010denih u prosjeku 6 mjeseci. Meta-analiza posebno se usredoto\u010dila na tri vrste napadaja u djetinjstvu (Dravet, Lennox-Gastaut i one uzrokovane nedostatkom CDKL5) i nastojala je opisati u\u010dinkovitost, potrebne doze i nuspojave povezane s kanabidiolom. Autori su nadalje analizirali razlike izme\u0111u ekstrakata bogatih CBD-om i izolata CBD-a. Epidiolex (farmaceutski CBD odobren od strane FDA) i neki neregulirani proizvodi CBD-a dobiveni iz konoplje smatraju se izolatima jer nemaju puni spektar drugih kanabinoida i terpena koji su prisutni u ekstraktima cijele biljke.<\/div>
71 % ljudi koji su koristili ekstrakte punog spektra CBD-a imali su smanjenu u\u010destalost napadaja, u usporedbi s 46% onih koji su koristili izolate CBD-a. Obje ove brojke su nevjerojatne. Tim vi\u0161e jer je ta populacija bila otporna na lije\u010denje, s obzirom na to da su tri godine prije kori\u0161tenja CBD-a isprobali izme\u0111u 4-12 lijekova. U drugom istra\u017eivanju na 272 pacijenta 14 % smatra da je konoplja neu\u010dinkovita u smanjenju napadaja, 15% do\u017eivjelo je smanjenje napadaja od 1-25 %, 28 % do\u017eivjelo je smanjenje od 76-99 %, a 10 % posto imalo je potpuni prestanak napada.<\/div>

DOZIRANJE<\/strong><\/h2>
U istra\u017eivanju provedenom od strane tri brazilska znanstvenika pokazala se dramati\u010dna razlika u dozama za CBD izolate u usporedbi s uljima punog spektra bogatim CBD-om. Prosje\u010dna doza za ljude koji su koristili \u010disti CBD izolat bila je 25,3 mg\/kg\/dan, ali za ekstrakte bogate CBD-om bila je 6,0 miligrama po kilogramu tjelesne mase osobe na dan. Kanabidiol punog spektra tako\u0111er se razlikovao od izolata CBD-a ni\u017eom stopom nuspojava. Izolat CBD-a bio je povezan s blagim nuspojavama u 73 % pacijenata, dok je CBD punog spektra bio povezan s blagim nuspojavama u samo 33 % slu\u010dajeva. Na po\u010detku kori\u0161tenja CBD-a oralnom konzumacijom za kontroliranje napada uzrokovanih epilepsijom, po\u010detna doza kre\u0107e se oko 1mg po kilogramu na dan podijeljeno u doze svakih 8 sati. Doze se pove\u0107avaju svakih 1-2 tjedna ovisno o rezultatima, no \u010dini se da je terapijski raspon za mnoge pacijente izme\u0111u 4-9 mg po kilogramu na dan.<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Nam vitae sapien dapibus, condimentum ipsum non, porttitor purus. Cras et diam ac \u2013 nunc urna magna, porttitor eu laoreet aliquam.<\/p>","protected":false},"author":1,"featured_media":8597,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[16],"tags":[],"class_list":["post-6530","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"\nEpilepsija i kanabinoidi - CALI<\/title>\n<meta name=\"description\" content=\"EPILEPSIJA I KANABINOIDI\u00a0 \u00a0 \u00a0Napadaji se javljaju kada dio mozga postane pretjerano uzbu\u0111en ili kada \u017eivci u mozgu po\u010dnu pucati na abnormalan na\u010din. Nagla neravnote\u017ea izme\u0111u okida\u010da ekscitacijskih i inhibitornih signala uzrokuje preuzimanje ekscitacijskih sila. 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