{"id":6544,"date":"2023-05-06T12:54:00","date_gmt":"2023-05-06T11:54:00","guid":{"rendered":"https:\/\/the7.io\/cbd\/?p=6544"},"modified":"2024-05-02T15:58:18","modified_gmt":"2024-05-02T13:58:18","slug":"post003","status":"publish","type":"post","link":"https:\/\/calishop.net\/en\/2023\/05\/06\/post003\/","title":{"rendered":"Akne i kanabinoidi"},"content":{"rendered":"
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Kako nastaju akne?<\/strong><\/h2>
\u00a0<\/div>
Kao osma najra\u0161irenija bolest, Acne vulgaris (akne) poga\u0111aju oko devet posto svjetske populacije. Iako su naj\u010de\u0161\u0107e kod adolescenata, mogu se pojaviti kod mla\u0111e djece te potrajati i kroz odraslu dob. Na\u017ealost, ova ra\u0161irena bolest povezana je s nelagodom, o\u017eiljcima na ko\u017ei, kao i emocionalnim i psihi\u010dkim tegobama.<\/div>
\u00a0<\/div>
Nadalje, zahva\u0107aju\u0107i 85 posto adolescenata, akne su \u010desto povezane sa zna\u010dajnim psihosocijalnim u\u010dincima uklju\u010duju\u0107i negativnu samopercepciju i samopo\u0161tovanje uz smanjene dru\u0161tvene interakcije i ukupnu kvalitetu \u017eivota. Unato\u010d tome, mogu\u0107nosti lije\u010denja i odgovor na lije\u010denje ostaju prevelike barijere.<\/div>
Akne su multifaktorska bolest; stoga, po\u010detak i napredovanje bolesti mo\u017ee biti potaknuto kombinacijom mnogih \u010dimbenika te stresa, hormonalnih i prehrambenih promjena. Patolo\u0161ki, akne su upalna bolest koja zahva\u0107a pilosebacealne jedinice. Takva se jedinica sastoji od folikula i stabla dlake te \u017elijezde lojnice. Sebacealne pore nalaze se na licu, prsima i le\u0111ima. Prekomjerna proizvodnja sebuma (hiperseboreja), abnormalno umno\u017eavanje ko\u017enih stanica (hiperkeratinizacija), nakupljanje Cutibacterium acnes (C. acnes) u pilosebacealnoj jedinici i upala klju\u010dni su za poreme\u0107aj aktivnosti \u017elijezda lojnica i patogenezu akni.<\/div>
\u00a0<\/div>

Lije\u010denje akni uz pomo\u0107 CBD-a<\/strong><\/h2>
\u00a0<\/div>
Lije\u010denje akni uklju\u010duje lokalno i sustavno lije\u010denje. Lokalni retinoidi kao \u0161to su tretinoin i eritromicin obi\u010dno se propisuju kao komedolitici i zbog svojih protuupalnih svojstava. Topikalne formulacije bez recepta koje sadr\u017ee salicilnu kiselinu i benzoil peroksid tako\u0111er se koriste kao baktericidna sredstva za lije\u010denje blagih do umjerenih akni. Sustavno lije\u010denje akni prvenstveno uklju\u010duje antibiotike tetraciklinske skupine, kao \u0161to su minociklin i doksiciklin. Ovi se oralni antibiotici obi\u010dno propisuju za umjerene do te\u0161ke akne. U bolesnika s vrlo te\u0161kim aknama kod kojih antibiotici vi\u0161e nisu u\u010dinkoviti, \u010desto se propisuje oralni izotretinoin za kontrolu prisutnosti C. acnes i smanjenje proizvodnje sebuma i upale. Osim toga, oralni kontraceptivi, poput onih s niskim dozama estrogena, tako\u0111er se mogu propisati za uporne akne za antiandrogene u\u010dinke.<\/div>
\u00a0<\/div>
\u00a0 \u00a0 \u00a0Kanabidiol je predlo\u017een kao obe\u0107avaju\u0107a terapeutska tvar za lije\u010denje acne vulgaris budu\u0107i da normalizira lipogenezu sebocitnih stanica (lipostatski u\u010dinak, bez ugro\u017eavanja stani\u010dne odr\u017eivosti), smanjuje proliferaciju tih stanica (antiproliferativni u\u010dinak, bez induciranja apoptoze sebocita) i smanjuje razine proupalnih citokina (protuupalni u\u010dinak).<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\u00a0 \u00a0 \u00a0U studiji koja je procjenjivala u\u010dinke CBD-a na ljudske \u017elijezde lojnice, CBD je valoriziran u kontekstu besmrtnih ljudskih sebocita u uvjetima “sli\u010dnim aknama”. Studija je pokazala da CBD, ovisno o dozi, inhibira prekomjernu sintezu lipida (lipogenezu) u kulturama sebocita koje su bile prethodno tretirane “pro-acne” spojevima koji izazivaju upale kao \u0161to su arahidonska kiselina, linolna kiselina i testosteron. Protuupalni u\u010dinci CBD-a tako\u0111er su primije\u0107eni u smanjenju upalnog citokina TNF-\u03b1. Lipopolisaharidi kori\u0161teni su za prethodnu obradu sebocita kako bi izazvali upalna stanja “pro-akne”. Zatim su koncentracije TNF-\u03b1 u sebocitima izmjerene nakon 24 sata sa ili bez CBD-a (10 \u03bcM). Utvr\u0111eno je da lije\u010denje CBD-om smanjuje ekspresiju mRNA TNF-\u03b1 i ekspresiju drugih upalnih citokina uklju\u010duju\u0107i IL-1\u03b2 i IL- 6 u sebocitima. Rezultati ove studije sna\u017eno pokazuju klini\u010dki potencijal CBD-a u lije\u010denju akni. U zasebnoj studiji, potencijalni u\u010dinci protiv akni drugog derivata biljke kanabisa, heksanskih ekstrakata sjemenki konoplje (HSHE), bili su procijenjeni u in vitro modelu akni.<\/p>

\u00a0 \u00a0 \u00a0Kao i CBD, ekstrakti sjemenki konoplje tako\u0111er ne pokazuju psihotropna svojstva i sugerira se da imaju potencijalne protuupalne u\u010dinke. U stani\u010dnoj liniji ljudskih keratinocita, 0,6% je HSHE smanjio upalu izazvanu C. acnes u ljudskim keratinocitima kroz regulaciju proupalnih citokina, IL-1\u03b2 i IL-8.37 Dodatno, utvr\u0111eno je da 0,6 posto HSHE zna\u010dajno inhibira prekomjernu proizvodnju upalnog radikalnog du\u0161ikova oksida u istim stanicama, dodatno podupiru\u0107i konvencionalni razvoj sastojaka dobivenih iz konoplje, kao \u0161to je HSHE kao prirodni, sigurni i u\u010dinkoviti protuupalni tretmani za akne. U studiji na ljudima koja je procjenjivala sigurnost i u\u010dinkovitost ekstrakata sjemenki kanabisa za akne, otkriveno je da tri posto ekstrakta sjemenki kanabisa smanjuje crvenilo ko\u017ee izazvano upalom, poznato kao eritem. Promjene u eritemu ko\u017ee mjerene su svaka 2 tjedna ukupno 12 tjedana.<\/p>

\u00a0 \u00a0 \u00a0Utvr\u0111eno je da lije\u010denje kremom s tripostotnim ekstraktom sjemenki kanabisa zna\u010dajno smanjuje eritem ko\u017ee nakon svakog dvotjednog promatranja, a zna\u010dajno postupno smanjenje eritema primije\u0107eno je tijekom dvanaestotjednog istra\u017eivanja. Nadalje, primjena tripostotnog ekstrakta sjemenki kanabisa kremom na obraze, dvaput dnevno, tijekom 12 tjedana pokazala se sigurnom, dobro podno\u0161ljivom, nealergenskom i neiritiraju\u0107om u bolesnika dobrovoljaca.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Etiam velit purus, vehicula quis imperdiet dignissim, convallis vitae nisl. Nullam facilisi. Pellentesque non pulvinar justo.<\/p>","protected":false},"author":1,"featured_media":8607,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[16],"tags":[],"class_list":["post-6544","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"\nAkne i kanabinoidi - CALI<\/title>\n<meta name=\"description\" content=\"Kao osma najra\u0161irenija bolest, Acne vulgaris (akne) poga\u0111aju oko devet posto svjetske populacije. 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