{"id":9826,"date":"2024-10-06T16:49:20","date_gmt":"2024-10-06T14:49:20","guid":{"rendered":"https:\/\/cali.hr\/?p=9826"},"modified":"2024-10-06T16:49:23","modified_gmt":"2024-10-06T14:49:23","slug":"konoplja-i-parkinsonova-bolest-potencijalna-terapija-buducnosti","status":"publish","type":"post","link":"https:\/\/calishop.net\/en\/2024\/10\/06\/konoplja-i-parkinsonova-bolest-potencijalna-terapija-buducnosti\/","title":{"rendered":"Konoplja i Parkinsonova bolest: Potencijalna terapija budu\u0107nosti"},"content":{"rendered":"
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Parkinsonova bolest (PD)<\/a> je tzv. dugotrajni neurodegenerativni poreme\u0107aj koji prvenstveno zahva\u0107a motorne funkcije, ali mo\u017ee utjecati i na mnoge druge aspekte \u017eivota oboljelih. Sprje\u010dava neometano kretanje i u raznim slu\u010dajevima uzrokuje kontinuirane tremore. I nemotori\u010dki simptomi mogu postati \u010de\u0161\u0107i s pogor\u0161anjem stanja. Sve zajedno \u010desto dovodi do trajnih motori\u010dkih, ali mentalnih problema. Dok tradicionalni tretmani, poput Levodope i drugih dopaminergi\u010dkih lijekova, poma\u017eu u ubla\u017eavanju simptoma, \u010desto dolazi do nuspojava i smanjenja u\u010dinkovitosti tijekom vremena. U tom kontekstu, istra\u017eiva\u010di sve vi\u0161e istra\u017euju alternativne terapije, uklju\u010duju\u0107i konoplju i njene aktivne komponente, zbog njihovih potencijalno blagotvornih u\u010dinaka na simptome Parkinsonove bolesti. Istra\u017eiva\u010di su sada znanstveno dokazali da bi kanabinoidi iz konoplje mogli igrati veliku ulogu u smanjenju odre\u0111enih simptoma poreme\u0107aja. Ljudima omiljeni kanabinoid kanabidiol (CBD) ipak pokazuje najve\u0107i potencijal protiv Parkinsonove bolesti.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Endokanabinoidni sustav i Parkinsonova bolest<\/strong><\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Endokanabinoidni sustav (ECS) ima klju\u010dnu ulogu u regulaciji brojnih fiziolo\u0161kih funkcija, poput raspolo\u017eenja, pokreta, boli i upalnih odgovora. Ovaj sustav, koji uklju\u010duje kanabinoidne receptore (CB1 i CB2), endogene kanabinoide (anandamid i 2-AG) te enzime koji razgra\u0111uju te molekule, nalazi se u sredi\u0161njem \u017eiv\u010danom sustavu, uklju\u010duju\u0107i dijelove mozga koji su klju\u010dni za motori\u010dku kontrolu, poput bazalnih ganglija.<\/p>

Kod osoba s Parkinsonovom bolesti dolazi do smanjenja dopamina u mozgu, \u0161to uzrokuje klasi\u010dne motori\u010dke simptome poput tremora, rigidnosti i bradikinezije. Sve ve\u0107i broj istra\u017eivanja pokazuje da kanabinoidi, poput onih iz biljke konoplje, mogu imati pozitivan utjecaj na ECS, pobolj\u0161avaju\u0107i simptome Parkinsonove bolesti kroz razli\u010dite mehanizme.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Pozitivni u\u010dinci kanabinoida kod Parkinsonove bolesti<\/strong><\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Smanjenje tremora i pobolj\u0161anje motori\u010dke funkcije<\/strong><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Prije svega, znamo da pacijenti s Parkinsonovom bole\u0161\u0107u \u010desto pate od tremora, iako je uko\u010denost mi\u0161i\u0107a tako\u0111er vrlo \u010dest simptom bolesti. Drugim rije\u010dima, poreme\u0107aj mo\u017ee sprije\u010diti istezanje ili opu\u0161tanje mi\u0161i\u0107a i pove\u0107ati napetost. Me\u0111utim, studije su otkrile da CBD ulje mo\u017ee znatno smanjiti ovu vrstu uko\u010denosti, ali i\u00a0 bol povezanu s njom. Kanabinoidi, poput kanabidiola (CBD), pokazuju potencijal za smanjenje motori\u010dkih simptoma Parkinsonove bolesti. Preliminarna istra\u017eivanja sugeriraju da kanabinoidi mogu smanjiti tremor i pobolj\u0161ati pokretljivost kod osoba s PD-om. Jedna studija iz 2014. godine objavljena u \u010dasopisu Clinical Neuropharmacology pokazala je kako su pacijenti s Parkinsonovom bolesti koji su konzumirali konoplju imali zna\u010dajno pobolj\u0161anje u finim motori\u010dkim vje\u0161tinama i smanjenje tremora.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Ubla\u017eavanje bolova<\/strong><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Mnogi pacijenti s Parkinsonovom bole\u0161\u0107u pate od kroni\u010dnih bolova uzrokovanih distonijom (nevoljni mi\u0161i\u0107ni gr\u010devi) i uko\u010deno\u0161\u0107u mi\u0161i\u0107a. CBD, ne-psihoaktivna komponenta konoplje, poznat je po svojim analgetskim svojstvima. Istra\u017eivanja su pokazala<\/a> da konoplja mo\u017ee zna\u010dajno smanjiti bolove povezane s PD, pru\u017eaju\u0107i olak\u0161anje bez \u0161tetnih nuspojava koje se \u010desto povezuju s opioidima i drugim lijekovima za ubla\u017eavanje boli. Kanabinoidi tako\u0111er mogu djelovati na CB1 i CB2 receptore kako bi modulirali percepciju boli i smanjili upalne procese koji pridonose pogor\u0161anju simptoma.
Nadalje, znamo da CBD ima sna\u017ena protuupalna svojstva na zglobove. To je pokazano u raznim studijama – i potencijalno bi moglo pomo\u0107i u smanjenju boli i uko\u010denosti kod pacijenata s Parkinsonovom bole\u0161\u0107u. U jednoj studiji iz 2011. godine<\/a>, provedenoj na \u0161takorima, primjerice, istra\u017eiva\u010di su otkrili kako kanabidiol mo\u017ee pomo\u0107i u smanjenju upale. Zbog jedinstvenog u\u010dinka koji kanabinoid ima na receptore boli i na\u010dina na koji reagiraju na podra\u017eaje.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Pobolj\u0161anje kvalitete sna<\/strong><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Nesanica i poreme\u0107aji spavanja \u010desti su problemi kod oboljelih od Parkinsonove bolesti. Ovi poreme\u0107aji mogu zna\u010dajno naru\u0161iti kvalitetu \u017eivota, a \u010desto su otporni na standardne terapije. Istra\u017eivanja pokazuju da CBD mo\u017ee pomo\u0107i u regulaciji ciklusa spavanja, smanjuju\u0107i nemir tijekom no\u0107i i omogu\u0107uju\u0107i pacijentima dulji i kvalitetniji san. Kanabinoidi mogu smanjiti REM poreme\u0107aje u spavanju, \u010dime se pacijentima omogu\u0107uje bolje no\u0107ni odmor, \u0161to zauzvrat poma\u017ee i u smanjenju dnevnog umora. Specifi\u010dna studija iz 2016.<\/a> zapravo pokazuje u\u010dinak CBD ulja na san kod pacijenata s Parkinsonovom bole\u0161\u0107u. Dokaz da ulje konoplje bogato CBD-om mo\u017ee pobolj\u0161ati kvalitetu sna kod pacijenata s Parkinsonovom bole\u0161\u0107u.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Smanjenje tjeskobe i depresije<\/strong><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Osim fizi\u010dkih simptoma koje pacijenti s Parkinsonovom bole\u0161\u0107u mogu osjetiti; poreme\u0107aj tako\u0111er mo\u017ee uzrokovati razne oblike halucinacija, iluzija, paranoje ili deluzija. To se javlja kod oko 20% svih pacijenata. Ve\u0107ina njih prvi put se susre\u0107e s ovim psihoti\u010dnim osobinama u kasnijoj fazi bolesti. Parkinsonova bolest \u010desto je pra\u0107ena psiholo\u0161kim simptomima poput tjeskobe i depresije, koji dodatno ote\u017eavaju \u017eivot oboljelih. Na\u017ealost, neki lijekovi koji se koriste protiv fizi\u010dkih simptoma Parkinsonove bolesti zapravo mogu pove\u0107ati mogu\u0107nost razvoja ovih psihoti\u010dnih epizoda. Nekoliko studija<\/a> pokazalo je da CBD, zbog svog anksioliti\u010dkog u\u010dinka, mo\u017ee zna\u010dajno smanjiti simptome tjeskobe i pobolj\u0161ati raspolo\u017eenje kod pacijenata s PD. CBD utje\u010de na serotoninergi\u010dki sustav u mozgu, poma\u017eu\u0107i regulirati razinu serotonina, \u0161to mo\u017ee doprinijeti osje\u0107aju smirenosti i op\u0107eg blagostanja.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Neuroprotektivni u\u010dinci kanabidiola<\/strong><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Osim svojih terapijskih u\u010dinaka na motori\u010dke simptome i raspolo\u017eenje, CBD pokazuje sna\u017ean potencijal kao neuroprotektivno sredstvo. Istra\u017eivanja na \u017eivotinjskim modelima<\/a> Parkinsonove bolesti sugeriraju da CBD, zbog svojih antioksidativnih svojstava, mo\u017ee smanjiti oksidativni stres i upalu u mozgu, \u0161to bi moglo usporiti napredovanje bolesti. Tijekom ove studije znanstvenici su tako\u0111er potvrdili sposobnost kanabinoida da umanje fizi\u010dke simptome; kao \u0161to su bol i usporenost. Ova svojstva CBD-a \u010dine ga privla\u010dnim kandidatom za dugoro\u010dne terapije koje bi mogle usporiti degenerativne procese i o\u010duvati neuronsku funkciju.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Pobolj\u0161anje kvalitete \u017eivota<\/strong><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Kao \u0161to vjerojatno mo\u017eete zamisliti, Parkinsonova bolest uvelike utje\u010de na kvalitetu \u017eivota pacijenata. O\u010dito, fizi\u010dki simptomi igraju veliku ulogu u tome. S obzirom na drhtanje, uko\u010denost, mogu\u0107i problemi s ravnote\u017eom i spori pokreti sigurno nisu od koristi. Kako smo ve\u0107 ranije naglasili, pacijenti s Parkinsonovom bole\u0161\u0107u tako\u0111er pate od emocionalnih i psihi\u010dkih o\u0161te\u0107enja zbog svoje bolesti.
Me\u0111utim, zahvaljuju\u0107i placebo kontroliranom in vivo istra\u017eivanju provedenom 2017.<\/a>, znamo da bi CBD mogao pomo\u0107i i ovdje. Sudionici studije koji su – nesvjesno – primili terapiju kanabinoidima, izvijestili su kako im je CBD doista pomogao pobolj\u0161ati kvalitetu \u017eivota.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Kanabinoidne terapije u klini\u010dkoj praksi<\/strong><\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Medicinska primjena konoplje za Parkinsonovu bolest jo\u0161 uvijek je u ranoj fazi istra\u017eivanja, ali sve vi\u0161e dr\u017eava i zemalja prepoznaje potencijal ove biljke i omogu\u0107uje njezinu uporabu kao dio terapije. Lijekovi koji sadr\u017ee kanabinoide, poput Sativexa (kombinacija THC-a i CBD-a), ve\u0107 su odobreni za lije\u010denje spasti\u010dnosti kod multiple skleroze, a sve je vi\u0161e klini\u010dkih studija koje istra\u017euju sli\u010dne pripravke za Parkinsonovu bolest.
Dok se jo\u0161 uvijek \u010deka na ve\u0107a randomizirana kontrolirana ispitivanja, sve vi\u0161e lije\u010dnika integrira kanabinoidne terapije u svoje pristupe lije\u010denju pacijenata s Parkinsonovom bole\u0161\u0107u. Zbog niske toksi\u010dnosti i povoljnih u\u010dinaka na niz simptoma, konoplja postaje sve relevantnija u pobolj\u0161anju kvalitete \u017eivota pacijenata.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Zaklju\u010dak<\/strong><\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Iako je potrebno provesti dodatna istra\u017eivanja kako bi se potpuno razumio potencijal konoplje u lije\u010denju Parkinsonove bolesti, trenutna istra\u017eivanja i klini\u010dka iskustva ukazuju na zna\u010dajan potencijal u pobolj\u0161anju motori\u010dkih i nemotori\u010dkih simptoma ove bolesti. Kanabinoidi, osobito CBD, nude obe\u0107avaju\u0107e terapijske mogu\u0107nosti, poma\u017eu\u0107i pacijentima u boljoj kontroli simptoma, smanjenju boli, pobolj\u0161anju sna i raspolo\u017eenja te op\u0107oj kvaliteti \u017eivota. Kako znanstvena zajednica nastavlja istra\u017eivati ovu fascinantnu biljku, mogu\u0107e je da \u0107e kanabinoidne terapije postati sastavni dio lije\u010denja Parkinsonove bolesti u budu\u0107nosti.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Linkovi<\/strong><\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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https:\/\/en.wikipedia.org\/wiki\/Parkinson’s_disease<\/p>

https:\/\/www.mdedge.com\/neurology\/article\/141080\/parkinsons-disease\/can-cannabis-help-patients-parkinsons-disease<\/p>

https:\/\/pubmed.ncbi.nlm.nih.gov\/21683763\/<\/p>

https:\/\/clinicaltrials.gov\/study\/NCT02818777<\/p>

https:\/\/journals.sagepub.com\/doi\/abs\/10.1177\/0269881108096519<\/p>

https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full\/10.1111\/j.1476-5381.2011.01278.x<\/p>

https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5436333\/<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Parkinsonova bolest (PD) je tzv. dugotrajni neurodegenerativni poreme\u0107aj koji prvenstveno zahva\u0107a motorne funkcije, ali mo\u017ee utjecati i na mnoge druge aspekte \u017eivota oboljelih. Sprje\u010dava neometano kretanje i u raznim slu\u010dajevima uzrokuje kontinuirane tremore. I nemotori\u010dki simptomi mogu postati \u010de\u0161\u0107i s pogor\u0161anjem stanja. Sve zajedno \u010desto dovodi do trajnih motori\u010dkih, ali mentalnih problema. Dok tradicionalni tretmani,…<\/p>","protected":false},"author":1,"featured_media":9859,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9826","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nKonoplja i Parkinsonova bolest: Potencijalna terapija budu\u0107nosti - CALI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Konoplja i Parkinsonova bolest: Potencijalna terapija budu\u0107nosti - CALI\" \/>\n<meta property=\"og:description\" content=\"Parkinsonova bolest (PD) je tzv. dugotrajni neurodegenerativni poreme\u0107aj koji prvenstveno zahva\u0107a motorne funkcije, ali mo\u017ee utjecati i na mnoge druge aspekte \u017eivota oboljelih. Sprje\u010dava neometano kretanje i u raznim slu\u010dajevima uzrokuje kontinuirane tremore. I nemotori\u010dki simptomi mogu postati \u010de\u0161\u0107i s pogor\u0161anjem stanja. Sve zajedno \u010desto dovodi do trajnih motori\u010dkih, ali mentalnih problema. 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